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Test Code LAB314 Fibrinogen, Clottable

Clinical Information

Identification of congenital afibrinogenemia, disseminated intravascular coagulation, and fibrinolytic activity.

Synonym

  • FIB
  • Factor I Activity
  • Fibrinogen Activity
  • Claus Fibrinogen

Specimen Required

Preferred Container/Tube: 3.2% Citrate Blue Top - 2.7 mL
Specimen Volume: 2.7 mL
Acceptable Container/Tube: 3.2% Citrate Blue Top - 1.8 mL
Specimen Volume: 1.8 mL
Platelet poor plasma (PPP):
Specimen Volume: 1 - 1 mL aliquots platelet poor plasma (PPP)
Specimen Minimum Volume: 1 - 0.5 mL aliquot platelet poor plasma (PPP)

Specimen Collection Information

For Outreach, other than OSU Patient Service Centers: Samples must be processed and received frozen/must remain frozen in transit. 

For sending frozen plasma specimens, process immediately upon receipt. Centrifuge capped specimen tube in accordance with CLSI H21, at a speed and time required to consistently produce platelet-poor plasma (PPP = platelet count <10 K/uL). Transfer PPP into plastic aliquot tubes, cap and freeze. DO NOT transport until specimens are completely frozen.

Specimen Stability Information

Ambient: 
     Whole blood: 4 hours
      Platelet poor plasma: 8 hours
Frozen: 
      Platelet poor plasma: PPP removed from the cells and frozen at -20°C or ideally -70°C.

Rejected Due To

  • Ambient WB specimens >4 hours old
  • Ambient PPP specimens >8 hours old
  • Clotted specimens
  • Underfilled or overfilled tube
  • Hemolysis
  • Icterus
  • Lipemia

Reference Values

220-410 mg/dL

Cautions

Increased in patients on oral contraceptives, pregnancy, or with active inflammatory processes. May be decreased in disseminated intravascular coagulation, severe liver disease, and congenital hypofibrinogenemia. Fibrinogen is insensitive to unfractionated heparin up to approximately 2 units/mL.

Method Description

Mechanical clot detection of dilute plasma in the presence of excess thrombin.

Performing Lab

Clinical Lab UH
Clinical Lab University East

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 day

Reporting Name

Fibrinogen, Clottable

CPT Code Information

85384

LOINC Code Information

3255-7