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Test Code IFLC Immunoglobulin Free Chains

Clinical Information

Elevated kappa and lambda (K/L) free light chain (FLC) may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance. A specific increase in FLC (e.g., FLC K:L ratio) must be demonstrated for diagnostic purposes. This assay has not been established for use with the pediatric population. Moderate-to-marked lipemia may interfere with the ability to perform testing.

Synonym

  • IFLC

Profile Information

Reporting Name Available Separately Always Reported
Kappa Free Light Chains No  Yes
Lambda Free Light Chains No Yes
Kappa/Lambda Ratio No Yes

Specimen Required

Preferred Container/Tube: Gold SST Top
Acceptable Container/Tube: Gold SST Top
Specimen Volume: 3 mL
Specimen Minimum Volume: 1 mL

Specimen Stability Information

Refrigerated: 21 days

Rejected Due To

  • Gross hemolysis
  • Gross lipemia
  • Microbially contaminated specimens
  • Samples containing particulate matter

Reference Values

Kappa Free Light Chains: 3.9-26.0 mg/L

Lambda Free Light Chains: 6.4-22.1 mg/L

Ratio: 0.51-1.72

Method Description

Turbidimetry

Performing Lab

Clinical Lab UH

Day(s) Performed

Monday through Friday (excludes OSU holidays)

Report Available

7 to 9 days

Reporting Name

Immunoglobulin Free Chains

CPT Code Information

83521 x2

LOINC Code Information

36916-5
33944-0
40844-3