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HelpTest Code LABCORDRG Toxicology Drug Screen, Umbilical Cord Segment
Clinical Information
The analysis of drugs in umbilical cord tissue (UCT) is intended to assess drug exposure during pregnancy. The presences or absence, deposition, concentration, and time frame of detectability for drugs in UCT does not necessarily parallel that of othe specimens such as meconium, newborn urine, and maternal urine. therefore, drugs detected or expected in maternal specimens and other newborn specimens may not match identified drugs in UCT. Drugs administered during labor may be present in UCT and negative results do not exclude the possibility of drug exposure during pregnancy.
Synonym
- CORDRG
- UCT
- Umbilical Cord
Profile Information
| Reporting Name | Available Separately | Always Reported |
|---|---|---|
| Amphetamine, Cord | No | Yes |
| Methamphetamine, Cord | No | Yes |
| 2-Hydroxyethylflurazepam, Cord | No | Yes |
| 7-Aminoclonazepam, Cord | No | Yes |
| 7-Aminoflunitrazepam, Cord | No | Yes |
| Alpha-OH-Alprazolam, Cord | No | Yes |
| Alpha-OH-Midazolam, Cord | No | Yes |
| Alprazolam, Cord | No | Yes |
| Clonazepam, Cord | No | Yes |
| Diazepam, Cord | No | Yes |
| Flurazepam, Cord | No | Yes |
| Lorazepam, Cord | No | Yes |
| Midazolam, Cord | No | Yes |
| Nordiazepam, Cord | No | Yes |
| Oxazepam, Cord | No | Yes |
| Temazepam, Cord | No | Yes |
| Buprenorphine, Cord | No | Yes |
| Norbuprenorphine, Cord | No | Yes |
| Cocaine, Cord | No | Yes |
| Benzoylecgonine, Cord | No | Yes |
| Fentanyl, Cord | No | Yes |
| Norfentanyl, Cord | No | Yes |
| Gabapentin, Cord | No | Yes |
| 6-Monoacetylmorphine, Cord | No | Yes |
| Ketamine, Cord | No | Yes |
| Norketamine, Cord | No | Yes |
| Methadone, Cord | No | Yes |
| Methadone Metabolite (EDDP), Cord | No | Yes |
| Methylphenidate, Cord | No | Yes |
| Ritalinic Acid, Cord | No | Yes |
| Codeine, Cord | No | Yes |
| Morphine, Cord | No | Yes |
| Hydrocodone, Cord | No | Yes |
| Hydromorphone, Cord | No | Yes |
| Naloxone, Cord | No | Yes |
| Meperidine, Cord | No | Yes |
| Normeperidine, Cord | No | Yes |
| Nalbuphine, Cord | No | Yes |
| Noroxycodone, Cord | No | Yes |
| Oxycodone, Cord | No | Yes |
| Oxymorphone, Cord | No | Yes |
| Phencyclidine (PCP), Cord | No | Yes |
| Pregabalin, Cord | No | Yes |
| Tramadol, Cord | No | Yes |
| Quetiapine, Cord | No | Yes |
| Mitragynine, Cord | No | Yes |
| Xylazine, Cord | No | Yes |
| Zolpidem, Cord | No | Yes |
| Zopiclone, Cord | No | Yes |
Specimen Required
Preferred Container/Tube: Cup
Acceptable Container/Tube: Sterile Cup
Specimen Volume: 6 inches of umbilical cord tissue
Specimen Minimum Volume: 3 inches of umbilical cord tissue
Specimen Collection Information
Take 6" cord segment and gently run cord segment between thumb and forefinger 3-4 times to remove residual blood. Rinse with saline and pat dry.
Specimen Stability Information
Refrigerated: 14 days
Frozen: 5 months stored less than -20C
Rejection Due To
- Quantity not sufficient
- Formalin fixed
Reference Values
None Detected
Cutoff concentrations:
Amphetamine 0.2 ng/g
Methamphetamine 0.5 ng/g
2-Hydroxyethylflurazepam 1.0 ng/g
7-Aminoclonazepam 0.2 ng/g
7-Aminoflunitrazepam 0.2 ng/g
alpha-Hydroxyalprazolam 1.0 ng/g
alpha-Hydroxymidazolam 0.2 ng/g
Alprazolam 0.1 ng/g
Clonazepam 10 ng/g
Diazepam 0.2 ng/g
Flurazepam 0.1 ng/g
Lorazepam 50 ng/g
Midazolam 0.2 ng/g
Nordiazepam 0.5 ng/g
Oxazepam 2.5 ng/g
Temazepam 0.5 ng/g
Buprenorphine 0.5 ng/g
Norbuprenorphine 0.5 ng/g
Cocaine 0.2 ng/g
Benzoylecgonine 0.5 ng/g
Fentanyl 0.5 ng/g
Norfentanyl 0.5 ng/g
Gabapentin 10 ng/g
6-Monoacetylmorphine 0.1 ng/g
Ketamine 0.1 ng/g
Norketamine 0.2 ng/g
Methadone 0.1 ng/g
EDDP Methadone 0.2 ng/g
Methylphenidate 0.1 ng/g
Ritalinic Acid 50 ng/g
Codeine 0.5 ng/g
Morphine 0.5 ng/g
Hydrocodone 0.2 ng/g
Hydromorphone 0.1 ng/g
Naloxone 0.2 ng/g
Meperidine 0.1 ng/g
Normeperidine 0.1 ng/g
Nalbuphine 0.5 ng/g
Noroxycodone 0.2 ng/g
Oxycodone 0.2 ng/g
Oxymorphone 0.5 ng/g
Phencyclidine 0.2 ng/g
Pregabalin 50 ng/g
Tramadol 0.1 ng/g
Quetiapine 0.2 ng/g
Mitragynine 0.5 ng/g
Xylazine 0.2 ng/g
Zolpidem 0.1 ng/g
Zopiclone 0.2 ng/g
Interpretation
Drugs and/or metabolites reported "Positive" were detected above the cutoff and indicate exposure to that drug/parent drug during gestation up to birth.
Drugs and/or metabolites reported "None Detected" were not detected above the cutoff. These results do NOT preclude the possibility that the mother used this drug during pregnancy.
Cautions
Detection of drugs in umbilical cord tissue is dependent on the concentration of the drug in the specimen. False negative results may occur if the drug concentration in umbilical cord tissue is below the cutoff. Negative results do not indicate that the mother did not use a drug during pregnancy. Interfering substances in umbilical cord tissue may impede the detection of certain drugs.
Drugs given to the mother during delivery may be detected in umbilical cord tissue.
Positive results do not indicate impairment.
Drugs detected in umbilical cord tissue may not parallel that of other specimens such as meconium, newborn urine, and maternal urine due to differences in drug deposition, concentration, and time of exposure.
Method Description
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Test Classification
This Liquid Chromatography/Mass Spectrometry (LC/MS/MS) test was developed and its performance characteristics determined by the Toxicology Laboratory at The Ohio State University Wexner Medical Center. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.
Performing Lab
Clinical Lab UH
Day(s) Performed
Monday through Friday
Report Available
1 to 3 days
Reporting Name
Toxicology, Umbilical Cord Segment
CPT Code Information
80324
80347
80348
80353
80354
80355
80356
80357
80358
80360
80364
80365
83992
80366
80373
80342
80323
80375
80368
G0480 x19 (if appropriate)
LOINC Code Information
29530-3
40381-6
59688-2
97212-5
61034-5
61037-8
97278-6
61038-6
61039-4
61074-1
61080-8
61044-4
59712-0
61051-9
61055-0
61061-8
82373-2
82375-7
40625-6
40609-0
61042-8
61051-9
103668-0
32099-4
61043-6
105974-0