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Test Code LAB459 Anti Phospholipid Antibody

Synonym

  • PLAB
  • Anticardiolipin Antibodies IgG, IgM
  • Antiphospholipid Antibodies IgG, IgM
  • Cardiolipin Antibodies IgG, IgM
  • Phospholipid Antibodies IgG, IgM

Profile Information

Reporting Name Available Separately Always Reported
Anti-Cardiolipin, IgG No Yes
Anti-Cardiolipin, IgM No Yes

Specimen Required

Preferred Container/Tube: 3.2% Citrate Blue Top - 2.7 mL
Acceptable Container/Tube: 3.2% Citrate Blue Top - 1.8 mL, Gold SST Top
Specimen Volume: 2 - 1 mL aliquots platelet poor plasma (PPP)
Specimen Minimum Volume: 1 - 1 mL aliquot platelet poor plasma (PPP)

Specimen Collection Information

Samples from outreach locations must be received as frozen plasma.  

For sending frozen specimens, process specimens immediately upon collection. Centrifuge capped specimen tube at a speed and time required to consistently produce platelet-poor plasma (platelet count <10 K/uL). Transfer plasma into plastic aliquot tubes and freeze. DO NOT transport until specimens are completely frozen and must remain frozen in transit.

Specimen Stability Information

Ambient: 
     Whole blood: 4 hours
      Platelet poor plasma: 4 hours
Frozen: 
      Platelet poor plasma: PPP removed from the cells and frozen at -20°C or ideally -70°C.

Rejected Due To

  • Ambient specimens >4 hours old
  • Clotted specimens
  • Underfilled or overfilled tube

Reference Values

Anti-Cardiolipin IgG: 0.0-20.0 CU

Anti-Cardiolipin IgM: 0.0-20.0 CU

Cautions

The immunoassay for phospholipid antibodies does not distinguish between autoantibodies and antibodies produced in response to infectious agents or as epiphenomena following thrombosis. For this reason, a single positive test result is not sufficient to meet accepted serologic criteria for the diagnosis of APS.

Method Description

Chemiluminescent two-step immunoassay

Performing Lab

Clinical Lab UH

Day(s) Performed

Monday through Friday (excludes OSU holidays)

Report Available

Same day/1 day

Reporting Name

Anti Phospholipids AB

CPT Code Information

86147 x2

LOINC Code Information

3181-5
3182-3