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Test Code LABB2GP1 Beta-2 Glycoprotein 1 Ab, IgG & IgM

Clinical Information

Beta-2-GPI autoantibodies are found in patients with antiphospholipid syndrome (APS) and are associated with increased risk of venous and arterial thrombosis and thrombocytopenia. Beta-2-GPI autoantibodies are found only in patients with autoimmune diseases, while cardiolipin autoantibodies can be transiently found in infectious diseases.

Synonym

  • B2GP1
  • β2GP1 IgG
  • B2GP1 IgG
  • β2GP1 IgM
  • B2GP1 IgM

Profile Information

Reporting Name Available Separately Always Reported
Beta-2 Glycoprotein 1 Ab, IgG No Yes
Beta-2 Glycoprotein 1 Ab, IgM No Yes

Specimen Required

Preferred Container/Tube: 3.2% Citrate Blue Top - 2.7 mL
Acceptable Container/Tube: 3.2% Citrate Blue Top - 1.8 mL, Gold SST Top
Platelet poor plasma (PPP):
Specimen Volume: 2 - 1 mL aliquots platelet poor plasma (PPP)
Specimen Minimum Volume: 1 - 1 mL aliquot platelet poor plasma (PPP)

Specimen Collection Information

Samples from outreach locations must be received as frozen plasma.  

For sending frozen specimens, process specimens immediately upon collection. Centrifuge capped specimen tube at a speed and time required to consistently produce platelet-poor plasma (platelet count <10 K/uL). Transfer plasma into plastic aliquot tubes and freeze. DO NOT transport until specimens are completely frozen and must remain frozen in transit.

Specimen Stability Information

Ambient: 
     Whole blood: 4 hours
      Platelet poor plasma: 4 hours
Frozen: 
      Platelet poor plasma: PPP removed from the cells and frozen at -20°C or ideally -70°C.

Rejected Due To

  • Ambient WB specimens >1 hour old
  • Ambient PPP specimens >4 hours old
  • Clotted specimens
  • Underfilled or overfilled tube

Reference Values

Beta-2 Glycoprotein 1 Ab, IgG: 0.0-20.0 CU

Beta-2 Glycoprotein 1 Ab, IgM: 0.0-20.0 CU

Method Description

Chemiluminescent two-step immunoassay

Performing Lab

Clinical Lab UH

Day(s) Performed

Monday through Friday (excludes OSU holidays)

Report Available

Same day/1 day

Reporting Name

Beta-2 Glycoprotein 1 Ab, IgG & IgM

CPT Code Information

86146 x2

LOINC Code Information

44448-9