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Test Code URN7 Amphetamines, Urine, Confirmation

Clinical Information

This test is intended to confirm the presence of d/l-amphetamine and/or d/l-methamphetamine in urine samples. This test cannot distinguish between the d/l isomers of amphetamine or methamphetamine. Detection of these drugs in urine indicates recent exposure but cannot be used to determine dosage or route of administration. Amphetamine is a metabolite of methamphetamine. Detection of both amphetamine and methamphetamine may indicate either methamphetamine-only exposure or co-exposure of methamphetamine and amphetamine.

Synonym

  • AMPC
  • Adderall
  • Meth
  • Speed

Specimen Required

Preferred Container/Tube: Urine Container
Acceptable Container/Tube: Urine Container
Specimen Volume: 5 mL
Specimen Minimum Volume: 1 mL

Specimen Stability Information

Ambient: 28 days
Refrigerated: 28 days
Frozen: 28 days

Rejected Due To

  • Quantity not sufficient

Reference Values

None Detected

 

Cutoff concentrations by liquid chromatography-tandem mass spectrometry:

Amphetamine: 25 ng/mL
Methamphetamine: 25 ng/mL

Interpretation

Numeric results (positive) indicate the measured concentration of drug in the urine sample. Negative results may reflect the absence of drug or drug present below the assay's limit of quantitation. The detection of drugs in urine is dependent on several factors including the amount of drug ingested, time since exposure, individual metabolism, kidney and liver function, urine concentration, and the assay's limit of detection.  Drug concentrations in urine cannot determine the dose, route of administration, or exact time of exposure.

Cautions

Detection of drugs in urine is dependent on urine concentration. False negative results may occur in urine that has been diluted either by direct sample tampering or by ingesting large quantities of water before sample collection.

Method Description

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Test Classification

This Liquid Chromatography/Mass Spectrometry (LC/MS/MS) test was developed and its performance characteristics determined by the Toxicology Laboratory at The Ohio State University Wexner Medical Center. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.

Performing Lab

Clinical Lab UH

Day(s) Performed

Monday through Friday

Report Available

2 to 7 days

Reporting Name

Amphetamines Confirmation, Urine

CPT Code Information

80324
G0480 (if appropriate)

LOINC Code Information

29592-3
17260-1