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HelpTest Code CHEM20 Aldosterone
Clinical Information
Based on 2025 Endocrine Society guidelines, screening for primary aldosteronism may be considered positive when:
- Renin is suppressed (direct renin concentration is less than or equal to 5.2 pg/mL) AND
- Plasma aldosterone concentration is greater than or equal to 10 ng/dL AND
- Aldosterone-renin ratio is >4.0
Notes: A suppressed renin (less than or equal to 5.2 pg/mL) with aldosterone 10-20 ng/dL may still be consistent with primary aldosteronism, even if the aldosterone-renin ratio is less than or equal to 4.0. Repeat testing in the morning may be needed.
Synonym
- ALDOS
- ALDNH
- ALDPRL
- ALDPRI
- ALDOPRR
- ALDPOL
- ALDPOI
- LDOPOR
Specimen Required
Preferred Container/Tube: Lavender Top
Acceptable Container/Tube: Lavender Top, Gold SST Top
Specimen Volume: 3 mL
Specimen Minimum Volume: 1 mL
Specimen Stability Information
Refrigerated: 5 days
Frozen: 4 weeks
Specimen Collection Information
EDTA Plasma: Blood should be collected aseptically by venipuncture. EDTA samples should be centrifuged in a non-refrigerated centrifuge. Remove the EDTA plasma from cells immediately after centrifugation.
Serum: Blood should be collected aseptically by venipuncture. Samples should be allowed to clot, and the serum separated from the clot as soon as possible.
For outreach, centrifuge specimen and aliquot the plasma/serum immediately after centrifugation. Send specimen refrigerated.
Rejected Due To
- Ambient specimens
Interpretation
Reference Range:
Plasma Upright: <35.30 ng/dL
Plasma Supine: <23.60 ng/dL
Serum Upright: <39.20 ng/dL
Serum Supine: <23.20 ng/dL
Method Description
Chemiluminescent immunoassay
Performing Lab
Clinical Lab UH
Day(s) Performed
Tuesday and Friday (excludes OSU holidays)
Report Available
2 to 4 days
Reporting Name
Aldosterone
CPT Code Information
82088
LOINC Code Information
1763-2