Clinical Information

This test alone should not be considered diagnostic. All other factors including the clinical history of the patients and other serological or biopsy results must also be taken into account. Staining patterns often change as a sample is titered out to end point. This is usually due to the presence of more than one autoantibody, especially for ANAs. A negative result can be due to disease remission or to the presence of autoantibodies not detectable by this technique.