Clinical Information

Insulin autoantibodies in human serum may interfere and cause discordant results. This assay has 100% cross-reactivity with recombinant human insulin (Novolin R and Novolin N), analogues of injectable insulin (i.e., insulin lispro, insulin detemir, insulin aspart, and insulin glargine). For assays employing antibodies, the possibility exists for interference by human anti-animal antibodies (i.e., heterophile antibodies) in the patient sample. Patients who have been regularly exposed to animals or have received immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments may produce antibodies, (e.g., HAMA), that interfere with immunoassays. This may falsely elevate or falsely decrease the results.