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Test Code LAB532 Renin

Clinical Information

The combined aldosterone/renin tests are preferred when screening for hyperaldosteronism. When prorenin, the inactive precursor of renin, is cryoactivated to renin during sample handling, falsely elevated results are obtained. Cryoactivation occurs when patient samples are chilled to temperatures of 4°C or below for extended periods of time, and when samples are chilled but still liquid (i.e., not frozen). Cryoactivation of prorenin to renin occurs more rapidly in serum. Prorenin blood concentration is approximately ten-fold greater than that of renin.

Synonym

  • RENIN
  • Direct

Specimen Required

Preferred Container/Tube: Lavender Top
Acceptable Container/Tube: Lavender Top
Specimen Volume: 3 mL
Specimen Minimum Volume: 1 mL

Specimen Stability Information

Frozen: 42 days

Specimen Collection Information

Do not pre-chill EDTA blood collection tubes nor store tubes on ice, but process blood at room temperature. Centrifuge tubes in a non-refrigerated centrifuge, separate EDTA-plasma from cells immediately after centrifugation, then aliquot and deep-freeze at –20°C or below instantly. Fasting specimens are recommended but not required. Record the time of day and the patient's posture during blood collection (supine, upright or seated).

Rejected Due To

  • Gross hemolysis
  • Microbially contaminated specimens
  • Samples containing particulate matter
  • Clotted

Reference Values

0-39 years: 4.2-52.2 pg/mL
40+ years: 3.6-81.6 pg/mL

Method Description

Chemiluminescent immunoassay

Performing Lab

Clinical Lab UH

Day(s) Performed

Tuesday (excludes OSU holidays)

Report Available

7 to 9 days

Reporting Name

Renin

CPT Code Information

84244

LOINC Code Information

35570-1