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Test Code LABALDOPNL Primary Aldosteronism Screening Panel

Clinical Information

Based on 2025 Endocrine Society guidelines, screening for primary aldosteronism may be considered positive when:
1. Renin is suppressed (direct renin concentration is less than or equal to 5.2 pg/mL) AND
2. Plasma aldosterone concentration is greater than or equal to 10 ng/dL AND
3. Aldosterone-renin ratio is >4.0

Notes: A suppressed renin (less than or equal to 5.2 pg/mL) with aldosterone 10-20 ng/dL may still be consistent with primary aldosteronism, even if the aldosterone-renin ratio is less than or equal to 4.0. Repeat testing in the morning may be needed. 

Synonym

  • ALDOS
  • RENIN
  • K

Profile Information

Reporting Name Available Separately Always Reported
Aldosterone Yes Yes
Renin Yes Yes
Potassium No  Yes

Specimen Required

Preferred Container/Tube: Mint Green Top and Lavender Top
Acceptable Container/Tube: Mint Green Top, Lavender Top, Gold SST Top
Specimen Volume: 3 mL
Specimen Minimum Volume: 1 mL

Specimen Stability Information

Aldosterone
Refrigerated: 5 days
Frozen: 4 weeks


Renin
Frozen: 42 days


Potassium
Ambient: 4 hours
Refrigerated: 5 days

Specimen Collection Information

Aldosterone
EDTA Plasma: Blood should be collected aseptically by venipuncture. EDTA samples should be centrifuged in a non-refrigerated centrifuge. Remove the EDTA plasma from cells immediately after centrifugation.
 
Serum: Blood should be collected aseptically by venipuncture. Samples should be allowed to clot, and the serum separated from the clot as soon as possible.
 
For outreach, centrifuge specimen and aliquot the plasma/serum immediately after centrifugation. Send specimen refrigerated. 

 

Renin
Do not pre-chill EDTA blood collection tubes nor store tubes on ice, but process blood at room temperature. Centrifuge tubes in a non-refrigerated centrifuge, separate EDTA-plasma from cells immediately after centrifugation, then aliquot and deep-freeze at –20°C or below instantly. Fasting specimens are recommended but not required. Record the time of day and the patient's posture during blood collection (supine, upright or seated).

Rejection Due To

  • Ambient specimens
  • Microbially contaminated specimens
  • Samples containing particulate matter
  • Clotted
  • Gross hemolysis
  • Gross icterus
  • Quantity not sufficient
  • Quality not acceptable

Reference Values

Potassium
0-7 days: 3.2-5.5 mmol/L
8-30 days: 3.4-6.0 mmol/L
31-182 days: 3.5-5.6 mmol/L
183-365 days: 3.5-6.1 mmol/L
1-17 years: 3.3-4.6 mmol/L
18+ years: 3.5-5.0 mmol/L

 

Renin
0-39 years: 4.2-52.2 pg/mL
40+ years: 3.6-81.6 pg/mL

 

Aldosterone
Plasma Upright: <35.30 ng/dL 
Plasma Supine: <23.60 ng/dL 
Serum Upright: <39.20 ng/dL 
Serum Supine: <23.20 ng/dL

Cautions

Potassium
Falsely elevated serum/plasma potassium measurements may occur with lysis of red or white blood cells or platelets during or after blood collection.

Method Description

Aldosterone and Renin
Chemiluminescent immunoassay

 

Potassium
Indirect ion-selective electrode

Performing Lab

Aldosterone and Renin
Clinical Lab UH

 

Potassium
Clinical Lab UH
Clinical Lab University East
Clinical Lab James
Clinical Lab Martha Morehouse
Clinical Lab Spielman
Clinical Lab West Campus

Day(s) Performed

Monday through Sunday

Report Available

7 to 9 days

Reporting Name

Aldosterone
Renin
Potassium

CPT Code Information

82088
84244
84132

LOINC Code Information

1763-2
35570-1
2823-3