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Test Code YFIGER IgE Receptor Antibody

Additional Codes

YFIGEB


Specimen Required


Container/Tube:

Preferred: Red top tube

Acceptable: Serum gel tube

Specimen Volume: 1.0 mL

Collection Instructions: Draw blood in a plain, red-top tube(s) or serum gel tube(s). Separate serum from cells immediately by centrifugation and aliquot in a polypropylene or similar plastic tube. Send 1 mL of serum frozen in plastic vial.


Useful For

The test detects functional autoantibodies to the Fc-epsilon receptor (high affinity IgE receptor) or to IgE and is useful in the evaluation of chronic urticaria.

Method Name

Flow Cytometry

Reporting Name

IgE Receptor Antibody

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 365 days
  Refrigerated  7 days
  Ambient  48 hours

Reject Due To

Hemolysis Mild OK; Gross reject
Lipemia NA
Icterus NA
Other NA

Reference Values

0-12

Interpretation

Chronic autoimmune urticaria (CIU) may be associated with autoantibodies to the high affinity IgE receptor (Fc-epsilon R1) or to IgE. In the presence of the autoantibodies, cross-linking of the Fc-epsilon-R1 receptor occurs, leading to basophil activation. The laboratory tests for the activation of donor basophils by CIU serum by analyzing the expression of the basophil specific ectoenzyme, CD203c. CD203c is upregulated on the surface of basophils following activation. A positive result is indicative of the presence of autoantibodies associated with CUI, but may also be due to other basophil-activating serum factors. Results must be correlated with clinical findings. The reference range was developed by the National Jewish Health Advanced Diagnostic Laboratories by analyzing 80 healthy control serum samples.

Day(s) Performed

Monday, Thursday

Report Available

11 to 14 days

Performing Laboratory

National Jewish Health

Test Classification

This test uses a kit/reagent designated by the manufacturer as "for research use, not for clinical use" as well as one or more reagents classified as an analyte specific reagent (ASR). The performance characteristics of this test have been validated by Advanced Diagnostic Laboratories at National Jewish Health. It has not been cleared or approved by the US Food and Drug Administration. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.

CPT Code Information

88184

88185 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FIERA IgE Receptor Antibody Not Provided

 

Result ID Test Result Name Result LOINC Value
Z5810 CD203c (Percent of Basophils) Not Provided
Z5811 Interpretation: Not Provided