Clinical Information

G6PD deficiency is the most common enzyme deficiency in the world, affecting an estimated 400 million people worldwide. It is more common in people of African, Mediterranean, and Asian descent. G6PD deficiency is an X-linked genetic disorder and, in general, affects males more than females. Severity ranges from mild to severe subtypes. Molecular genetic testing may also be indicated in cases where the disorder is suspected, or where there is a family history of G6PD deficiency, as enzyme activity may be normal in heterozygous females.